Based on the popular song of the same name, Cien por Uno tells the story of Agustín Quintero, a respected lieutenant of the Cabrillo Cartel. Despite not agreeing with his sister’s relationship with Alejandro, he gives him work inside the cartel. Unfortunately, his suspicions about his brother-in-law were true. Alejandro betrays him and makes a pact with the Colombians. Now, Agustín has no choice but to face the Colombians if he wants to survive.